Article
Mutagenic and recombinogenic consequences of DNA-repair inhibition during treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea in Saccharomyces cerevisiae.
Mutation research - 1 Aug 1990
Ferguson L R
Abstract excerpt
The yeast Saccharomyces cerevisiae has been used as a model system to explore whether the clinical combination of the antitumour agent BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) with DNA-repair inhibitors would affect the drug's mutagenic or recombinogenic potential. Preliminary experiments suggested that mitotic crossing-over and other mutagenic events are controlled in a separate fashion. BCNU was more toxic...
Topics
- Amsacrine
- Caffeine
- Carmustine
- Crossing Over, Genetic
- DNA Repair
- Hydroxyurea
- Mutagenicity Tests
- Mutation
- Saccharomyces cerevisiae