Article
Induction of mitotic crossing-over by the topoisomerase II poison DACA (N-[2-dimethylamino)ethyl]acridine-4-carboxamide) in Saccharomyces cerevisiae.
Mutation research - 1 Oct 1993
Ferguson L R, Turner P M, Baguley B C
Abstract excerpt
The antitumor agent DACA (N-[2-dimethylamino)ethyl]acridine-4-carboxamide) a new DNA intercalating topoisomerase II poison, was distinguishable from clinical topoisomerase poisons (amsacrine, daunorubicin, doxorubicin and etoposide) in its induction of aberrant colonies in the yeast Saccharomyces...
Topics
- Acridines
- Adenosine Triphosphatases
- Aminoacridines
- Antineoplastic Agents
- Cell Division
- Crossing Over, Genetic
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Intercalating Agents
- Mutagenicity Tests
- Mutation
- Rad52 DNA Repair and Recombination Protein
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Topoisomerase II Inhibitors