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Article

DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugs.

Molecular pharmacology - 1 Jun 2004

Beljanski Vladimir, Marzilli Luigi G, Doetsch Paul W

Abstract excerpt

We used a panel of isogenic Saccharomyces cerevisiae strains compromised in several different DNA damage-processing pathways to assess in vivo processing of DNA adducts induced by four cross-linking anticancer drugs. By examining cytotoxicity profiles, cell cycle arrest patterns, and determining recombination and mutation frequencies, we found that cisplatin-, nitrogen mustard-, mitomycin-, and carmustine-induced...

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Identifiers

PMID: 15155842
DOI: 10.1124/mol.65.6.1496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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