Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization.

International journal of radiation oncology, biology, physics - 1 Aug 2006

Allen Bryan G, Johnson Monika, Marsh Anne E, Dornfeld Kenneth J

Abstract excerpt

PURPOSE: Increased cellular sensitivity to ionizing radiation due to thymidine depletion is the basis of radiosensitization with fluoropyrimidine and methotrexate. The mechanism responsible for cytotoxicity has not been fully elucidated but appears to involve both the introduction of uracil into, and its removal from, DNA. The role of base excision repair of uracil and oxidatively damaged bases in creating the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endodeoxyribonucleases
Share to Folic Acid Antagonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydroxylamines

Share to Rad52 DNA Repair and Recombination Protein

Share to Thymidine

Share to Thymine Nucleotides

Share to Uracil

Share to Uracil-DNA Glycosidase

Source

Identifiers

PMID: 16863931
DOI: 10.1016/j.ijrobp.2006.03.051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization.PMID 16863931Read ↗

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation.Semantic proximity Read ↗

Antifolate response in replication arrest mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugs.Semantic proximity Read ↗

Yeast base excision repair: interconnections and networks.Semantic proximity Read ↗

Nucleotide excision repair deficiency causes elevated levels of chromosome gain in Saccharomyces cerevisiae.Semantic proximity Read ↗

Inactivation of RAD52 and HDF1 DNA repair genes leads to premature chronological aging and cellular instability.Semantic proximity Read ↗

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.Semantic proximity Read ↗

Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae.Semantic proximity Read ↗

Relative contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae.Semantic proximity Read ↗

Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.