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Article

Enhancement of the recombinagenic and mutagenic activities of bleomycin in yeast by intercalation of acridine compounds into DNA.

Mutagenesis - 1 Jul 2009

Hoffmann George R, Ronan Matthew V, Sylvia Katelyn E, Tartaglione Jason P

Abstract excerpt

Strain D7 of Saccharomyces cerevisiae was used to measure the induction by bleomycin (BLM) of mitotic recombination at the trp5 locus and point mutations at ilv1 in the presence and absence of acridine compounds. BLM is a potent mutagen and recombinagen in the D7 assay. The acridines vary, some being mutagenic or recombinagenic and others not. Combined treatments were used to distinguish whether a genetically...

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PMID: 19406902
DOI: 10.1093/mutage/gep012

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BLM

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