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Article

Genotoxic and recombinogenic activities of the two beta-carboline alkaloids harman and harmine in Saccharomyces cerevisiae.

Mutation research - 20 Mar 2002

Boeira Jane Marlei, Viana Alice Fialho, Picada Jaqueline Nascimento, Henriques João Antonio Pêgas

Abstract excerpt

The cytotoxical beta-carboline alkaloids harman and harmine occur in medical plants and in a variety of foods, alcoholic beverages, and industrial waste. We applied them to the yeast Saccharomyces cerevisiae to test for putative genotoxicity, mutagenicity and recombinogenicity and to determine whether harman and harmine produced repairable DNA damage. Harmine was more cytotoxic than harman for exponentially...

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PMID: 11890933
DOI: 10.1016/s0027-5107(01)00294-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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