Article
Anti-recombinogenic and convertible co-mutagenic effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted pyrimidine nucleoside analogs in S. cerevisiae MP1.
Mutation research - 11 Nov 1996
Fahrig R
Abstract excerpt
In experiments using yeast, without addition of an external metabolic activation system, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was co-mutagenic and showed an insignificant anti-recombinogenic effect in combination with triethylene melamine (TEM). In the presence of activating S9-mix, the an...
Topics
- Animals
- Bromodeoxycytidine
- Bromodeoxyuridine
- Deoxycytidine
- Dose-Response Relationship, Drug
- Genes, Fungal
- Heterozygote
- Idoxuridine
- Liver
- Male
- Mutagens
- Mutation
- Rats
- Recombination, Genetic
- Saccharomyces cerevisiae
- Triethylenemelamine
- Trifluridine