Modulation of bleomycin-induced mitotic recombination in yeast by the aminothiols cysteamine and WR-1065.

doi:10.1007/BF00287098

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Article

Modulation of bleomycin-induced mitotic recombination in yeast by the aminothiols cysteamine and WR-1065.

Molecular & general genetics : MGG - 10 Dec 1995

Hoffmann G R, Quaranta J L, Shorter R A, Littlefield L G

Abstract excerpt

The cancer chemotherapy drug bleomycin (BLM) is a potent inducer of genetic damage in a wide variety of assays. The radioprotectors cysteamine (CSM) and WR-1065 have been shown in previous studies to potentiate the induction of micronuclei and chromosome aberrations by BLM in Go human lymphocytes...

Topics

Alleles
Antibiotics, Antineoplastic
Bleomycin
Cysteamine
Fungal Proteins
Gene Conversion
Gene Expression Regulation, Fungal
Mercaptoethylamines
Mitosis
Mutagenesis
Oxygen
Saccharomyces cerevisiae

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