Article
Low cytotoxicity of ecteinascidin 743 in yeast lacking the major endonucleolytic enzymes of base and nucleotide excision repair pathways.
Biochemical pharmacology - 1 Jul 2005
Soares Daniele Grazziotin, Poletto Nadine Paese, Bonatto Diego, Salvador Mirian, Schwartsmann Gilberto, Henriques João Antonio Pêgas
Abstract excerpt
Ecteinascidin 743 (ET-743) is a promising antitumoral drug for the treatment of soft tissues sarcomas, becoming a good candidate for clinical trials. However, the molecular mechanism of how ET-743 induces cells death is poorly understood. The chemical structure of ET-743 suggests that it can form cytotoxic cross-links with proteins and DNA. Experiments with Escherichia coli and mammalian cells indicate that the...
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