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Article

In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.

Virology - 5 Dec 2011

Zhang Ao, Bogerd Hal, Villinger Francois, Das Gupta Jaydip, Dong Beihua, Klein Eric A, Hackett John, Schochetman Gerald, Cullen Bryan R, Silverman Robert H

Abstract excerpt

The gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), replicates to high titers in some human cell lines and is able to infect non-human primates. To determine whether APOBEC3 (A3) proteins restrict XMRV infections in a non-human primate model, we sequenced proviral DNA from peripheral blood mononuclear cells of XMRV-infected rhesus macaques. Hypermutation characteristic of A3DE, A3F and A3G...

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Identifiers

PMID: 21982221
DOI: 10.1016/j.virol.2011.08.030
PMCID: PMC3208790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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