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Article

Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.

Journal of virology - 1 Dec 2007

Miyagi Eri, Opi Sandrine, Takeuchi Hiroaki, Khan Mohammad, Goila-Gaur Ritu, Kao Sandra, Strebel Klaus

Abstract excerpt

APOBEC3G (APO3G) is a cellular cytidine deaminase with potent antiviral activity. Initial studies of the function of APO3G demonstrated extensive mutation of the viral genome, suggesting a model in which APO3G's antiviral activity is due to hypermutation of the viral genome. Recent studies, however, found that deaminase-defective APO3G mutants transiently expressed in virus-producing cells exhibited significant...

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Identifiers

PMID: 17928335
DOI: 10.1128/JVI.01361-07
PMCID: PMC2168852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.PMID 17928335Read ↗

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