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Article

Mechanism of membrane interaction and disruption by α-synuclein.

Journal of the American Chemical Society - 7 Dec 2011

Reynolds Nicholas P, Soragni Alice, Rabe Michael, Verdes Dorinel, Liverani Ennio, Handschin Stephan, Riek Roland, Seeger Stefan

Abstract excerpt

Parkinson's disease is a common progressive neurodegenerative condition, characterized by the deposition of amyloid fibrils as Lewy bodies in the substantia nigra of affected individuals. These insoluble aggregates predominantly consist of the protein α-synuclein. There is increasing evidence suggesting that the aggregation of α-synuclein is influenced by lipid membranes and, vice versa, the membrane integrity is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21978222
DOI: 10.1021/ja2029848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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