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Article

The behavior of alpha-synuclein in neurons.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2010

Fortin Doris L, Nemani Venu M, Nakamura Ken, Edwards Robert H

Abstract excerpt

Despite considerable evidence linking alpha-synuclein with membranes in vitro, it has proven difficult to demonstrate membrane association of the protein in vivo. alpha-Synuclein localizes to the nerve terminal, but biochemical experiments have not revealed a tight association with membranes. To address the dynamics of the protein in live cells, we have used photobleaching and found that alpha-synuclein exhibits...

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PMID: 20187244
DOI: 10.1002/mds.22722

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