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Article

Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.

Journal of molecular biology - 1 Feb 2008

Stöckl Martin, Fischer Patricia, Wanker Erich, Herrmann Andreas

Abstract excerpt

Previous studies indicate that binding of alpha-synuclein to membranes is critical for its physiological function and the development of Parkinson's disease (PD). Here, we have investigated the association of fluorescence-labeled alpha-synuclein variants with different types of giant unilamellar vesicles using confocal microscopy. We found that alpha-synuclein binds with high affinity to anionic phospholipids,...

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Identifiers

PMID: 18082181
DOI: 10.1016/j.jmb.2007.11.051

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