Article

Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies

2025-09-16

Abstract excerpt

Conformational variations in α-syn fibrils are thought to underlie the distinct clinical features of synucleinopathies, including Lewy body dementia (LBD), Parkinsons’s disease (PD), and multiple system atrophy (MSA), suggesting that distinct fibril structures act as molecular fingerprints linked to disease phenotype. While the origins of these conformational variations remain unclear, increasing evidence points t...

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Literature Corpus work: f944e66c-6825-548e-a8af-d4769f3070d0
DOI: 10.1101/2025.09.10.675439

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