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Article

Aggregation and membrane activity of mutant A30P alpha-synuclein on mitochondrial membranes.

International journal of biological macromolecules - 1 Apr 2026

Herrera Maja, El Saghir Adam, Mansueto Silvia, Ghio Stephanie, Fusco Giuliana, De Simone Alfonso, Vassallo Neville

Abstract excerpt

The A30P point mutation in the α-synuclein (α-syn) protein is linked to a familial form of Parkinson's disease (PD), the most common motor neurodegenerative disorder. The association of α-syn with lipids in cellular membranes plays a key role in modulating the aggregation behavior of the protein, as well as its toxicity. Here, we studied the impact of the A30P mutation on the interaction of α-syn with...

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Identifiers

PMID: 41856188
DOI: 10.1016/j.ijbiomac.2026.151491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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