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Article

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

Science (New York, N.Y.) - 15 Dec 2017

Fusco Giuliana, Chen Serene W, Williamson Philip T F, Cascella Roberta, Perni Michele, Jarvis James A, Cecchi Cristina, Vendruscolo Michele, Chiti Fabrizio, Cremades Nunilo, Ying Liming, Dobson Christopher M, De Simone Alfonso

Abstract excerpt

Oligomeric species populated during the aggregation process of α-synuclein have been linked to neuronal impairment in Parkinson's disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, we identified the fundamental characteristics that enable toxic α-synuclein oligomers to perturb biological membranes...

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Identifiers

PMID: 29242346
DOI: 10.1126/science.aan6160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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