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Article

Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity.

Neurobiology of disease - 1 Jul 2015

Ysselstein Daniel, Joshi Mehul, Mishra Vartika, Griggs Amy M, Asiago Josephat M, McCabe George P, Stanciu Lia A, Post Carol Beth, Rochet Jean-Christophe

Abstract excerpt

The post-mortem brains of individuals with Parkinson's disease (PD) and other synucleinopathy disorders are characterized by the presence of aggregated forms of the presynaptic protein α-synuclein (aSyn). Understanding the molecular mechanism of aSyn aggregation is essential for the development of neuroprotective strategies to treat these diseases. In this study, we examined how interactions between aSyn and...

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Identifiers

PMID: 25931201
DOI: 10.1016/j.nbd.2015.04.007
PMCID: PMC4458405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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