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Article

α-Synuclein insertion into supported lipid bilayers as seen by in situ X-ray reflectivity.

ACS chemical neuroscience - 18 Mar 2015

Hähl Hendrik, Möller Isabelle, Kiesel Irena, Campioni Silvia, Riek Roland, Verdes Dorinel, Seeger Stefan

Abstract excerpt

Large aggregates of misfolded α-synuclein inside neuronal cells are the hallmarks of Parkinson's disease. The protein's natural function and its supposed toxicity, however, are believed to be closely related to its interaction with cell and vesicle membranes. Upon this interaction, the protein folds into an α-helical structure and intercalates into the membrane. In this study, we focus on the changes in the lipid...

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PMID: 25523270
DOI: 10.1021/cn5002683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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