Early induction of anti-double-stranded DNA antibodies in lupus-prone MRL mice inoculated with Ly-24+ cells cloned from lymph node cells of an MRL/Mp-lpr/lpr mouse: possible effect of putative cytokines produced by cloned Ly-24+ cells.

doi:10.1016/0165-2478(90)90035-o

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Article

Early induction of anti-double-stranded DNA antibodies in lupus-prone MRL mice inoculated with Ly-24+ cells cloned from lymph node cells of an MRL/Mp-lpr/lpr mouse: possible effect of putative cytokines produced by cloned Ly-24+ cells.

Immunology letters - 1 Jan 2000

Kanai Y, Isonishi S, Katagiri T, Koizumi T, Miura K, Kurosawa Y

Abstract excerpt

We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination revealed that KML1-7 cells cloned from the cell line KML1 were only positive for the Lys-24...

Topics

Animals
Antibodies, Antinuclear
Antigens, Surface
Biological Factors
Cell Line
Clone Cells
Cytokines
DNA
Female
Immunoglobulin G
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymph Nodes

Male

Mice

Mice, Inbred Strains

Mice, Mutant Strains

Phenotype

Receptors, Lymphocyte Homing

Source

Open in PubMed

Identifiers

PMID: 2197220
DOI: 10.1016/0165-2478(90)90035-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2197220-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Early induction of anti-double-stranded DNA antibodies in lupus-prone MRL mice inoculated with Ly-24+ cells cloned from lymph node cells of an MRL/Mp-lpr/lpr mouse: possible effect of putative cytokines produced by cloned Ly-24+ cells.PMID 2197220Read ↗

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