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Article

Experimental lupus nephritis in severe combined immunodeficient (SCID) mice: remodelling of the glomerular lesions by bystander IgM antibodies.

Clinical and experimental immunology - 1 Feb 2000

Ito M R, Terasaki S, Kondo E, Shiwaku H, Fukuoka Y, Nose M

Abstract excerpt

MRL/Mp-lpr/lpr (MRL/lpr) mice develop glomerular lesions with regular variations in their histopathological manifestations, similar to those in lupus nephritis. These lesions are mainly either cell-proliferative or wire loop-like and are associated with glomerular deposits of immunoglobulins, most frequently IgG and IgM. We previously established a nephritogenic IgG3-producing hybridoma clone, B1, from an MRL/lpr...

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Identifiers

PMID: 10632673
DOI: 10.1046/j.1365-2249.2000.01133.x
PMCID: PMC1905503

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Source receipt: pubmed, retrieved 7 Sept 2026.

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