Article
V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1993
Bloom D D, Davignon J L, Retter M W, Shlomchik M J, Pisetsky D S, Cohen P L, Eisenberg R A, Clarke S H
Abstract excerpt
Anti-Sm autoantibodies are unique to SLE, but are present in only 25% of patients with this disease. This response also occurs at a similar frequency in mice of the autoimmune MRL strains. Previous analyses of the anti-Sm response in these mice indicate that its occurrence is controlled by stochastic events, and suggest that Sm is the driving Ag. To further elucidate the role of Ag in this response, and to test...
Topics
- Amino Acid Sequence
- Animals
- Autoantibodies
- Autoantigens
- Base Sequence
- Clone Cells
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin kappa-Chains
- Lupus Erythematosus, Systemic