Article
Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1992
Losman M J, Fasy T M, Novick K E, Monestier M
Abstract excerpt
MRL/Mp(-)+/+ mice produce antinuclear antibodies and develop a spontaneous autoimmune syndrome with lupus-like nephritis. We obtained a panel of seven histone-reactive IgG mAb from a single MRL/Mp(-)+/+ mouse. These antibodies do not react significantly with DNA or individual histones, but bind s...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Autoantibodies
- Autoimmune Diseases
- Base Sequence
- DNA
- Epitopes
- Female
- Genes, Immunoglobulin
- Histones
- Immunoglobulin Variable Region
- Lupus Nephritis
- Mice
- Molecular Sequence Data
- Mutation
- Nucleosomes