Article
Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of lymph node stromal cells in lpr-lymphadenopathy.
Immunobiology - 1 Nov 1992
Ohnishi-Inoue Y, Yasumizu R, Sugiura K, Nagata N, Fan H, Oyaizu N, Inaba M, Toki J, Ikehara S
Abstract excerpt
To clarify the mechanism by which the lpr gene causes lymphadenopathy, we established an experimental system to induce lymph node (LN) swelling in unaffected mice. In MRL-(+)/+ mice that had been 5 Gy-irradiated and grafted with bone marrow cells (BMCs) plus LN from MRL-lpr/lpr mice, a remarkable...
Topics
- Animals
- Autoimmune Diseases
- Bone Marrow Transplantation
- Fibroblasts
- Genes
- Genotype
- Hypertrophy
- Immunotherapy, Adoptive
- Lymph Nodes
- Lymphatic Diseases
- Lymphoproliferative Disorders
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains
- Mice, Mutant Strains
- Phenotype
- Radiation Chimera