Long-term anti-CD4 treatment of MRL/lpr mice ameliorates immunopathology and lymphoproliferation but fails to suppress rheumatoid factor production.

doi:10.1016/s0090-1229(05)80013-3

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Article

Long-term anti-CD4 treatment of MRL/lpr mice ameliorates immunopathology and lymphoproliferation but fails to suppress rheumatoid factor production.

Clinical immunology and immunopathology - 1 Dec 1991

O'Sullivan F X, Ray C J, Takeda Y, Sharp G C, Walker S E

Abstract excerpt

MRL/lpr mice were treated with anti-CD4 mAb to define the role of CD4+ T cells in the pathogenesis of autoimmune disease and the lymphoproliferation characteristic of the strain. Anti-CD4 treatment was not associated with adverse effects, and survival of treated mice was increased over that of rat IgG-treated controls. Renal function was preserved, and the histologic severity of glomerulonephritis was minimal in...

Topics

Animals
Antibodies
Antibody Formation
Autoantibodies
Autoimmune Diseases
CD4 Antigens
Cell Division
Female
Immunoglobulin G
Immunoglobulin M
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Mice

Mice, Mutant Strains

Phenotype

Rheumatoid Factor

Time Factors

Source

Open in PubMed

Identifiers

PMID: 1934630
DOI: 10.1016/s0090-1229(05)80013-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1934630-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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