Article
Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.
The Journal of experimental medicine - 1 Jul 1990
Ohteki T, Seki S, Abo T, Kumagai K
Abstract excerpt
MRL-lpr/lpr mice develop a severe autoimmune disease that resembles systemic lupus erythematosis in humans. The predominant immunological feature in these mice is the development of peripheral lymphadenopathy due to the expansion of an unusual T cell subset (TCR-alpha/beta +5CD3+4-8-B220+), which...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Autoimmune Diseases
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Cell Count
- Cell Division
- Cytotoxicity Tests, Immunologic
- Cytotoxicity, Immunologic
- Female
- Fluorescent Antibody Technique
- In Vitro Techniques
- Kinetics
- Liver
- Lupus Erythematosus, Systemic
- Lymphoid Tissue