Article
A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice.
Clinical immunology and immunopathology - 1 May 1994
Gonzalo J A, Tarazona R, Schuurman H J, Uytdehaag F, Wick G, Martínez C, Kroemer G
Abstract excerpt
MRL/Mp-lpr/lpr (MRL/lpr) mice carry a mutation in the Fas gene whose product is involved in the regulation of lymphocyte apoptosis. This mutation is associated with the lpr phenomenon, i.e., a massive expansion of phenotypically abnormal CD4-CD8- cells ("double negative," DN) alpha/beta T cells (...
Topics
- Animals
- Autoimmune Diseases
- Autoimmunity
- CD4-CD8 Ratio
- Depression, Chemical
- Enterotoxins
- Female
- Immunosuppressive Agents
- Injections, Intravenous
- Lymphocyte Activation
- Mice
- Mice, Mutant Strains
- Mutation
- Staphylococcus aureus
- Superantigens
- T-Lymphocytes
- Time Factors