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A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice.

Clinical immunology and immunopathology - 1 May 1994

Gonzalo J A, Tarazona R, Schuurman H J, Uytdehaag F, Wick G, Martínez C, Kroemer G

Abstract excerpt

MRL/Mp-lpr/lpr (MRL/lpr) mice carry a mutation in the Fas gene whose product is involved in the regulation of lymphocyte apoptosis. This mutation is associated with the lpr phenomenon, i.e., a massive expansion of phenotypically abnormal CD4-CD8- cells ("double negative," DN) alpha/beta T cells (lpr cells) that becomes manifest at 3-4 months of age. As in normal mice, intravenous SEB injection into 2- or...

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PMID: 8181186
DOI: 10.1006/clin.1994.1069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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