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Article

Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells

1 Apr 1992

Abstract excerpt

The mechanisms by which anti-DNA MoAbs derived from MRL-lpr/lpr mice, bind to human umbilical vein endothelial cells (HUVEC) and glomerular mesangial cells were studied using a cellular ELISA. DNAse-treatment of either the MoAb or HUVEC followed by reconstitution with DNA and/or histones was performed to determine whether DNA and histones mediated such binding. It was found that MoAb410 bound to HUVEC and...

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PMID: 1563108
DOI: 10.1111/j.1365-2249.1992.tb03041.x

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