Article
High expression of interleukin-1beta in the corneal epithelium of MRL/lpr mice is under the control of their genetic background.
Clinical and experimental immunology - 1 May 2004
Okamoto M, Takagi M, Kutsuna M, Hara Y, Nishihara M, Zhang M C, Matsuda T, Sakanaka M, Okamoto S, Nose M, Ohashi Y
Abstract excerpt
MRL/Mp mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop polyarthritis, sialoadenitis and dacryoadenitis, resembling rheumatoid arthritis (RA), and also corneal involvement such as keratopathy and scleritis, which is a major complication in RA patients. In this study, we found that the expression levels of IL-1beta and MMP-1 mRNAs in cornea were high in both MRL/lpr and MRL/Mp-+/+...
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