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Article

Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.

The Journal of experimental medicine - 6 Sept 1999

Brard F, Shannon M, Prak E L, Litwin S, Weigert M

Abstract excerpt

Antibodies to single-stranded (ss)DNA are expressed in patients with systemic lupus erythematosus and in lupus-prone mouse models such as the MRL/Mp-lpr/lpr (MRL/lpr) strain. In nonautoimmune mice, B cells bearing immunoglobulin site-directed transgenes (sd-tgs) that code for anti-ssDNA are functionally silenced. In MRL/lpr autoimmune mice, the same sd-tgs are expressed in peripheral B cells and these...

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Light Chain

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Share to Lupus Erythematosus, Systemic

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Share to Mice, Inbred MRL lpr

Source

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Identifiers

PMID: 10477553
DOI: 10.1084/jem.190.5.691
PMCID: PMC2195620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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