Article
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Science (New York, N.Y.) - 30 Sept 2011
Arnon Tal I, Xu Ying, Lo Charles, Pham Trung, An Jinping, Coughlin Shaun, Dorn Gerald W, Cyster Jason G
Abstract excerpt
Lymphocytes egress from lymphoid organs in response to sphingosine-1-phosphate (S1P); minutes later they migrate from blood into tissue against the S1P gradient. The mechanisms facilitating cell movement against the gradient have not been defined. Here, we show that heterotrimeric guanine nucleotide-binding protein-coupled receptor kinase-2 (GRK2) functions in down-regulation of S1P receptor-1 (S1PR1) on...
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