Article
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration.
The Journal of biological chemistry - 9 Apr 2004
Allende Maria L, Dreier Jennifer L, Mandala Suzanne, Proia Richard L
Abstract excerpt
S1P(1) is a widely distributed G protein-coupled receptor whose ligand, sphingosine 1-phosphate, is present in high concentrations in the blood. The sphingosine 1-phosphate receptor-signaling pathway is believed to have potent effects on cell trafficking in the immune system. To determine the precise role of the S1P(1) receptor on T-cells, we established a T-cell-specific S1P(1) knock-out mouse. The mutant mice...
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