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Article

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.

PloS one - 1 Jan 2009

Vogel Peter, Donoviel Michael S, Read Robert, Hansen Gwenn M, Hazlewood Jill, Anderson Stephen J, Sun Weimei, Swaffield Jonathan, Oravecz Tamas

Abstract excerpt

BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism. Because S1P modulates a wide range of physiological processes, its concentration must be tightly regulated within both intracellular and extracellular environments. METHODOLOGY: In order to better understand the function of S1PL in this regulatory pathway, we assessed the...

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Identifiers

PMID: 19119317
DOI: 10.1371/journal.pone.0004112
PMCID: PMC2606024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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