Article
Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.
Scientific reports - 9 Aug 2017
Mashud Rana, Nomachi Akira, Hayakawa Akihide, Kubouchi Koji, Danno Sally, Hirata Takako, Matsuo Kazuhiko, Nakayama Takashi, Satoh Ryosuke, Sugiura Reiko, Abe Manabu, Sakimura Kenji, Wakana Shigeharu, Ohsaki Hiroyuki, Kamoshida Shingo, Mukai Hideyuki
Abstract excerpt
Knock-in mice lacking PKN1 kinase activity were generated by introducing a T778A point mutation in the catalytic domain. PKN1[T778A] mutant mice developed to adulthood without apparent external abnormalities, but exhibited lower T and B lymphocyte counts in the peripheral blood than those of wild-type (WT) mice. T and B cell development proceeded in an apparently normal fashion in bone marrow and thymus of...
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