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Article

Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery.

The Journal of allergy and clinical immunology - 1 Aug 2016

Resop Rachel S, Douaisi Marc, Craft Joshua, Jachimowski Loes C M, Blom Bianca, Uittenbogaart Christel H

Abstract excerpt

BACKGROUND: The mechanisms that govern the egress of mature thymocytes from the human thymus to the periphery remain understudied yet are of utmost importance to the field of basic immunology, as well as T-cell reconstitution in various immunodeficiencies. We examined the expression and function of sphingosine-1-phosphate (S1P) receptors in human thymocyte egress. OBJECTIVES: We aimed to determine whether S1P...

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Source

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Identifiers

PMID: 27056271
DOI: 10.1016/j.jaci.2015.12.1339
PMCID: PMC7007110

Genes

KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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