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Article

Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.

Blood - 15 Jun 2005

Jolly Puneet S, Bektas Meryem, Watterson Kenneth R, Sankala Heidi, Payne Shawn G, Milstien Sheldon, Spiegel Sarah

Abstract excerpt

Mast cells play a central role in inflammatory and immediate-type allergic reactions by secreting a variety of biologically active substances, including sphingosine-1 phosphate (S1P). Sphingosine kinase 1 (SphK1) and formation of S1P, which leads to transactivation of S1P receptors and their downstream signaling pathways, regulates mast-cell functions initiated by cross-linking of the high-affinity immunoglobulin...

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Identifiers

PMID: 15741218
DOI: 10.1182/blood-2004-12-4686
PMCID: PMC1894993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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