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Article

An ALS-associated mutant SOD1 protein can be eliminated in microglia culture by selective autophagy.

Neuroscience - 27 Mar 2026

Murakami Kumiko, Sudou Norihiro, Kurata Atushi, Kawaguchi-Niida Motoko

Abstract excerpt

The acquired toxicity of the familial amyotrophic lateral sclerosis (ALS)-associated mutant Zn-superoxide dismutase 1 (SOD1) protein has been implicated in motoneuron death, and cytosolic aggregates or inclusions have been observed in the cytoplasm of motoneurons, astrocytes, and neuronal axons but not in that of microglia. This study elucidates the mechanisms by which mutant SOD1 does not aggregate in and is...

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Identifiers

PMID: 41579929
DOI: 10.1016/j.neuroscience.2026.01.017

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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