Article
The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2009
D'Ambrosi Nadia, Finocchi Pamela, Apolloni Savina, Cozzolino Mauro, Ferri Alberto, Padovano Valeria, Pietrini Grazia, Carrì Maria Teresa, Volonté Cinzia
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective loss of lower and upper motoneurons. The pathology is imputable in approximately 2% of cases to mutations in the ubiquitous enzyme Cu, Zn superoxide dismutase (SOD1). Common theories to explain the pathogenic mechanisms of ALS include activation of microglia, responsible for the release of proinflammatory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.