Article
The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms.
PLoS genetics - 1 Jan 2012
White Travis B, Lambowitz Alan M
Abstract excerpt
Mobile group II introns are bacterial retrotransposons that are thought to have invaded early eukaryotes and evolved into introns and retroelements in higher organisms. In bacteria, group II introns typically retrohome via full reverse splicing of an excised intron lariat RNA into a DNA site, where it is reverse transcribed by the intron-encoded protein. Recently, we showed that linear group II intron RNAs, which...
Topics
- Animals
- DNA Damage
- DNA End-Joining Repair
- DNA Ligases
- Drosophila melanogaster
- Introns
- Mutation
- RNA
- RNA Splicing
- RNA-Directed DNA Polymerase
- Retroelements