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Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

18 Dec 2008

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a telomere length maintenance mechanism based on recombination, where telomeres use other telomeric DNA as a template for DNA synthesis. About 10% of all human tumors depend on ALT for their continued growth, and understanding its molecular details is critically important for the development of cancer treatments that target this mechanism. We have previously shown...

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Identifiers

PMID: 19095716
DOI: 10.1093/hmg/ddn436

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