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Article

EXO1 plays a role in generating type I and type II survivors in budding yeast.

Genetics - 1 Apr 2004

Maringele Laura, Lydall David

Abstract excerpt

Telomerase-defective budding yeast cells escape senescence by using homologous recombination to amplify telomeric or subtelomeric structures. Similarly, human cells that enter senescence can use homologous recombination for telomere maintenance, when telomerase cannot be activated. Although recombination proteins required to generate telomerase-independent survivors have been intensively studied, little is known...

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Source

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Identifiers

PMID: 15126386
DOI: 10.1534/genetics.166.4.1641
PMCID: PMC1470825

Genes

EXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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EXO1 plays a role in generating type I and type II survivors in budding yeast.PMID 15126386Read ↗

EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase.Semantic proximity Read ↗

An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence.Semantic proximity Read ↗

Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.Semantic proximity Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.Semantic proximity Read ↗

EXO1-A multi-tasking eukaryotic nuclease.Semantic proximity Read ↗

Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.Semantic proximity Read ↗

Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Semantic proximity Read ↗

SGS1 is required for telomere elongation in the absence of telomerase.Semantic proximity Read ↗

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