Article
Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.
Kidney international - 1 Jan 2013
Lipkowitz Michael S, Freedman Barry I, Langefeld Carl D, Comeau Mary E, Bowden Donald W, Kao W H Linda, Astor Brad C, Bottinger Erwin P, Iyengar Sudha K, Klotman Paul E, Freedman Richard G, Zhang Weijia, Parekh Rulan S, Choi Michael J, Nelson George W, Winkler Cheryl A, Kopp Jeffrey B
Abstract excerpt
Despite intensive antihypertensive therapy there was a high incidence of renal end points in participants of the African American Study of Kidney Disease and Hypertension (AASK) cohort. To better understand this, coding variants in the apolipoprotein L1 (APOL1) and the nonmuscle myosin heavy chain 9 (MYH9) genes were evaluated for an association with hypertension-attributed nephropathy and clinical outcomes in a...
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