Article
Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease.
Kidney international - 1 Oct 2012
Freedman Barry I, Langefeld Carl D, Turner Jolyn, Núñez Marina, High Kevin P, Spainhour Mitzie, Hicks Pamela J, Bowden Donald W, Reeves-Daniel Amber M, Murea Mariana, Rocco Michael V, Divers Jasmin
Abstract excerpt
Familial aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk. To detect genetic associations with milder forms of nephropathy in the high-risk families, analyses were performed using generalized estimating equations to assess relationships between kidney disease phenotypes and APOL1 variants in 786...
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