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Article

Using zinc finger nucleases for efficient and heritable gene disruption in zebrafish.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010

McCammon Jasmine M, Amacher Sharon L

Abstract excerpt

While the experimental tools developed for zebrafish have continued to advance the organism as a laboratory model, techniques for reverse genetics remain somewhat limited in scope. Zinc finger nucleases (ZFNs), chimeric fusions between DNA-binding zinc finger proteins and the non-specific cleavage domain of the FokI endonuclease, hold great promise for targeted mutagenesis in zebrafish, as demonstrated by two...

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Identifiers

PMID: 20680842
DOI: 10.1007/978-1-60761-753-2_18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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