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Genome Engineering at the Dawn of the Golden Age

24 May 2013

Abstract excerpt

Genome engineering--the ability to precisely alter the DNA information in living cells--is beginning to transform human genetics and genomics. Advances in tools and methods have enabled genetic modifications ranging from the "scarless" correction of a single base pair to the deletion of entire chromosomes. Targetable nucleases are leading the advances in this field, providing the tools to modify any gene in...

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PMID: 23701416
DOI: 10.1146/annurev-genom-091212-153435

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