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Article

Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

PloS one - 1 Jan 2009

Foley Jonathan E, Yeh Jing-Ruey J, Maeder Morgan L, Reyon Deepak, Sander Jeffry D, Peterson Randall T, Joung J Keith

Abstract excerpt

BACKGROUND: Customized zinc finger nucleases (ZFNs) form the basis of a broadly applicable tool for highly efficient genome modification. ZFNs are artificial restriction endonucleases consisting of a non-specific nuclease domain fused to a zinc finger array which can be engineered to recognize specific DNA sequences of interest. Recent proof-of-principle experiments have shown that targeted knockout mutations can...

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Identifiers

PMID: 19198653
DOI: 10.1371/journal.pone.0004348
PMCID: PMC2634973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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