Article
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design.
Nature - 14 Sept 2011
Dymond Jessica S, Richardson Sarah M, Coombes Candice E, Babatz Timothy, Muller Héloïse, Annaluru Narayana, Blake William J, Schwerzmann Joy W, Dai Junbiao, Lindstrom Derek L, Boeke Annabel C, Gottschling Daniel E, Chandrasegaran Srinivasan, Bader Joel S, Boeke Jef D
Abstract excerpt
Recent advances in DNA synthesis technology have enabled the construction of novel genetic pathways and genomic elements, furthering our understanding of system-level phenomena. The ability to synthesize large segments of DNA allows the engineering of pathways and genomes according to arbitrary s...
Topics
- Attachment Sites, Microbiological
- Chromosomes, Artificial, Yeast
- Directed Molecular Evolution
- Gene Dosage
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Genetic Engineering
- Genetic Fitness
- Genome, Fungal