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Article

Heterozygous diploid and interspecies SCRaMbLEing.

Nature communications - 22 May 2018

Shen Michael J, Wu Yi, Yang Kun, Li Yunxiang, Xu Hui, Zhang Haoran, Li Bing-Zhi, Li Xia, Xiao Wen-Hai, Zhou Xiao, Mitchell Leslie A, Bader Joel S, Yuan Yingjin, Boeke Jef D

Abstract excerpt

SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution) is a genome restructuring technique that can be used in synthetic genomes such as that of Sc2.0, the synthetic yeast genome, which contains hundreds to thousands of strategically positioned loxPsym sites. SCRaMbLE has been used to induce rearrangements in yeast strains harboring one or more synthetic chromosomes, as well as...

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Identifiers

PMID: 29789590
DOI: 10.1038/s41467-018-04157-0
PMCID: PMC5964232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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