Article

Functional characterisation of an essential neo-chromosome III in Sc2.0 strain reveals opportunities and challenges for genome minimisation in Sc3.0

2026-04-22

Abstract excerpt

<h4> Abstract </h4> Large-scale genome minimisation in eukaryotes remains a major challenge due to essential genes embedded within deletion-refractory regions and pervasive synthetic lethal interactions. Here, we address these limitations by engineering an essential neo–chromosome III that relocates all 14 essential genes from synthetic chromosome III onto a separate chromosome, thereby enabling further minimisa...

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Literature Corpus work: c383864f-f5a1-54df-a0e3-2d5ea51f6cac
DOI: 10.64898/2026.04.20.719597

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Functional characterisation of an essential neo-chromosome III in Sc2.0 strain reveals opportunities and challenges for genome minimisation in Sc3.0DOI 10.64898/2026.04.20.719597Read

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