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Article

Precise control of SCRaMbLE in synthetic haploid and diploid yeast.

Nature communications - 22 May 2018

Jia Bin, Wu Yi, Li Bing-Zhi, Mitchell Leslie A, Liu Hong, Pan Shuo, Wang Juan, Zhang Hao-Ran, Jia Nan, Li Bo, Shen Michael, Xie Ze-Xiong, Liu Duo, Cao Ying-Xiu, Li Xia, Zhou Xiao, Qi Hao, Boeke Jef D, Yuan Ying-Jin

Abstract excerpt

Compatibility between host cells and heterologous pathways is a challenge for constructing organisms with high productivity or gain of function. Designer yeast cells incorporating the Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) system provide a platform for generating genotype diversity. Here we construct a genetic AND gate to enable precise control of the SCRaMbLE...

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Identifiers

PMID: 29789567
DOI: 10.1038/s41467-018-03084-4
PMCID: PMC5964104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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